Work-family conflict is one of the important challenges in Iranian government organizations that affects the performance of employees and their family life. This study was conducted with the aim of meta-analyzing the antecedents of work-family conflict in Iranian government organizations. This study is quantitative and meta-analytic. The statistical population included all research related to the antecedents of work-family conflict in Iranian government organizations. By searching for keywords such as "work-family conflict" in databases such as Jihad Daneshgaghi, Humanities Portal, Noor Mags, Google, and Magiran, 809 documents were identified. After reviewing, 40 documents with 87 hypotheses were selected using purposive sampling. Data were collected using the documentary method and the logbook tool and analyzed using the Hunter and Schmidt statistical approach. The findings showed that the average combined effect size was 0.384, which is within the confidence limit and indicates a significant effect of factors on work-family conflict. Factors such as the year of the study, gender of employees, type of organization, type of variables, and geographical region were identified as moderating factors. The results indicate that social, cultural, and family factors, despite their high impact, have been ignored in existing research and this requires more attention. Gender differences and geographical location of employees also affect the intensity of work-family conflict, and men in particular are more exposed to conflicts compared to women and employees of decentralized organizations.