Today, with the occurrence of extensive and intensive changes in the business environment, only institutions are able to continue their activities that can create innovation in their organization. The approach of quantum skills and quantum leadership enables the managers of organizations to innovate in the organization. This study has been conducted with the aim of identifying the impact of skills and quantum leadership on increasing innovation in organizations. This research is descriptive-composite method and practical in terms of purpose. The population studied in this research consists of employees working in non-governmental organizations. The sampling method is stratified random and data collection is done through a questionnaire. Using Morgan's table, 130 employees were selected as samples. Data analysis was done using the structural equation modeling method. The results showed that there is a relationship between quantum skills and quantum leadership, quantum leadership and organizational innovation, innovation and service delivery , innovation and production processes , innovation and organizational behavior , innovation and strategy , there is a positive and significant relationship, thus it can be said that today one of the important responsibilities of managers is to strengthen quantum skills and adopt quantum leadership in institutions.